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Theilmann, David, Ph.D.

Directeur de recherche intérimaire et chercheur scientifique, virologie moléculaire des insectes

Coordonnées :

4200 Highway 97
C.P. 5000
Summerland, (Colombie-Britannique) V0H 1Z0
Téléphone : 250-494-6395
Télécopieur : 250-494-0755
Courriel : david.theilmann@agr.gc.ca

Domaines d'expertise :

  • maladies des insectes - virales
  • génomique
  • virologie moléculaire
  • entomologie
  • lutte biologique
  • expression génique

Projets en cours :

  • Interactions fonctionnelles in vivo entre un pathogène baculovirus et l'intestin moyen de ses hôtes, les lépidoptères nuisibles
  • Analyse globale de l'expression des gènes particulière à un tissu durant l'infection de Mamestra configurata, un organisme nuisible du canola, par son pathogène baculovirus, MacoNPV
  • Analyses moléculaires des protéines du baculovirus requises pour l'attachement à l'intestin moyen de son hôte, le lépidoptère nuisible du canola Mamestra configurata, et l'infection de celui-ci
  • Analyses moléculaires du pathogène baculovirus pour l'organisme nuisible de serres Trichoplusia ni
  • Mise sur pied de plate-formes de génomique et de protéomique appliquées à l'intestin moyen menant à l'identification de nouveaux insectes cibles pour une résistance accrue

Affiliations :

  • Professeur auxiliaire, Faculté des systèmes des terres et des aliments, Université de la Colombie-Britannique
  • Professeur auxiliaire, Département de zoologie, Université de la Colombie-Britannique
  • Conseiller en analyse génomique des baculovirus, Banque génétique des National Institutes of Health, base de données sur les acides nucléiques et les protéines
  • Membre, Biocontrol Network
  • Membre et ancien président, Groupe d'étude sur les baculovirus, Comité international de taxonomie des virus

Publications de recherche

2017

  • Harrison, R.L., Mowery, J.D., Rowley, D.L., Bauchan, G.R., Theilmann, D.A., Rohrmann, G.F., Erlandson, M.A. (2018). The complete genome sequence of a third distinct baculovirus isolated from the true armyworm, Mythimna unipuncta, contains two copies of the lef-7 gene, 54(2), 297-310. http://dx.doi.org/10.1007/s11262-017-1525-0
  • Harrison, R.L., Rowley, D.L., Mowery, J., Bauchan, G.R., Theilmann, D.A., Rohrmann, G.F., Erlandson, M.A. (2017). The complete genome sequence of a second distinct betabaculovirus from the true armyworm, Mythimna unipuncta, 12(1), http://dx.doi.org/10.1371/journal.pone.0170510
  • Javed, M.A., Coutu, C., Theilmann, D.A., Erlandson, M.A., Hegedus, D.D. (2019). Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles, 26(3), 424-440. http://dx.doi.org/10.1111/1744-7917.12547
  • Simón, O., Erlandson, M.A., Frayssinet, M., Williams, T., Theilmann, D.A., Volkoff, A.N., Caballero, P. (2017). Lacanobia oleracea nucleopolyhedrovirus (LaolNPV): A new European species of alphabaculovirus with a narrow host range, 12(4), http://dx.doi.org/10.1371/journal.pone.0176171

2016

  • Donly, B.C., Kaplanoglu, E., Theilmann, D.A., Baldwin, D., Sieminska, E., Hegedus, D.D., Erlandson, M.A. (2016). MacoNPV baculovirus midgut-specific gene expression during infection of the bertha armyworm, Mamestra configurata, 499 1-8. http://dx.doi.org/10.1016/j.virol.2016.09.001
  • Javed MA, Biswas S, Willis LG, Harris S, Pritchard C, van Oers MM, Donly BC, Erlandson MA, Hegedus DD, Theilmann DA. 2017. Autographa californica multiple nucleopolyhedrovirus AC83 is a per os infectivity factor (PIF) protein required for occlusion-derived virus (ODV) and budded virus nucleocapsid assembly as well as assembly of the PIF complex in ODV envelopes. J Virol 91:e02115-16.
  • Javed, M.A., Harris, S., Willis, L.G., Theilmann, D.A., Donly, B.C., Hegedus, D.D., Erlandson, M.A. (2016) Microscopic investigation of AcMNPV infection in the Trichoplusia ni midgut. J. Invert. Pathology. 141:24-33.
  • Rohrmann, G.F., Erlandson, M.A., et Theilmann, D.A. (2015). « A distinct group II alphabaculovirus isolated from a Peridroma species. », Genome Announcements, 3(2: e00185-15), p. 1-1. doi : 10.1128/genomeA.00185-15

2015

  • Rohrmann, G.F., Erlandson, M.A., et Theilmann, D.A. (2015). « Genome sequence of an alphabaculovirus isolated from the oak looper, Lambdina fiscellaria, contains a putative 2-kbp transposable element encoding a transposase and the FLYWCH domain-containing protein. », Genome Announcements, 3(3: e00186-15), p. 1-2. doi : 10.1128/genomeA.00186-15

2014

2013

  • Rohrmann, G.F., Erlandson, M.A., et Theilmann, D.A. (2013). « The genome of a baculovirus isolated from Hemileuca sp. Encodes a serpin ortholog. », Virus Genes, 47(2), p. 357-364. doi : 10.1007/s11262-013-0951-x

2012

  • Dickison, V.L., Willis, L.G., Sokal, N., et Theilmann, D.A. (2012). « Deletion of AcMNPV ac146 eliminates the production of budded virus. », Virology, 431(1-2), p. 29-39. doi : 10.1016/j.virol.2012.05.002
  • Nie, Y.C., Fang, M.G., Erlandson, M.A., et Theilmann, D.A. (2012). « Analysis of the Autographa californica Multiple Nucleopolyhedrovirus Overlapping Gene Pair lef3 and ac68 Reveals that AC68 Is a Per Os Infectivity Factor and that LEF3 Is Critical, but Not Essential, for Virus Replication. », Journal of Virology, 86(7), p. 3985-3994. doi : 10.1128/JVI.06849-11
  • Peng, K., van Lent, J.W.M., Boeren, S., Fang, M.G., Theilmann, D.A., Erlandson, M.A., Vlak, J.M., et van Oers, M.M. (2012). « Characterization of novel components of the baculovirus per os infectivity factor (PIF) complex. », Journal of Virology, 86(9), p. 4981-4988. doi : 10.1128/JVI.06801-11
  • Toprak, U., Harris, S., Baldwin, D., Theilmann, D.A., Gillott, C., Hegedus, D.D., et Erlandson, M.A. (2012). « The role of enhancin in Mamestra configurata nucleopolyhedrovirus virulence: Selective degradation of host peritrophic matrix proteins. », Journal of General Virology, 93(4), p. 744-753. doi : 10.1099/vir.0.038117-0

2011

2010

2009

Autres publications relatives à la science

2016

  • Donly, C., Kaplanoglu, E., Theilmann, D., Hegedus, D., Baldwin, D., Siemenska, E., Erlandson, M. (2016) Measuring the Mamestra configurata Nucleopolyhedrosis Virus Transcriptome: Personalized Insect Genomics. Insect Biotech Conference, St. Catharines, Ontario. 8-10 June 2016, oral presentation.

2015

  • Erlandson, M.A., Harris, S., Sieminska, E.A., Baldwin, D., Hegedus, D.D., et Theilmann, D.A. (2015). « Inhibition of Cotesia vanessae development in Trichoplusia ni larvae infected with alphabaculoviruses from Mamestra configurata. », 48th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Vancouver, B.C., Canada, August 9-13, 2015, Oral Presentation.
  • Harrison, R.L., Theilmann, D.A., et Erlandson, M.A. (2015). « Genome sequence analysis of a two alphabaculoviruses and a betabaculovirus from armyworms of the genus Mythimna. », 48th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Vancouver, B.C., Canada, August 9-13, 2015. (Affiche)
  • Javed, M.A., Harris, S., Theilmann, D.A., Erlandson, M.A., et Hegedus, D.D. (2015). « AcMNPV infection process in Trichoplusia ni midgut. », 48th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Vancouver, B.C., Canada, August 9-13, 2015. (Affiche)
  • Theilmann, D.A., Willis, L.G., Weis, M.M., Donly, B.C., Hegedus, D.D., et Erlandson, M.A. (2015). « Analysis of occlusion derived virus infection in tissue culture using gene knock out viruses of the per os infectivity factors and GP64. », 48th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Vancouver, B.C., Canada, August 9-13, 2015, Oral Presentation.

2014

  • Baldwin, D., Theilmann, D.A., Vlak, J.M., et Erlandson, M.A. (2014). « Genomic variation of Mamestra configurata nucleopolyhedroviruses from noctuid host species across Holarctic regions. », 2014 Joint Annual Meeting of Entomological Society of Saskatchewan and Entomological Society of Canada, Saskatoon SK, Canada, September 28-October 1, 2014. (Affiche)
  • Biswas, S., Blissard, G.W., et Theilmann, D.A. (2014). « Analysis of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) AC141 (EXON0) interaction with the lepidoptern Trichoplusia ni (T. ni) kinesin-1. », XVIth International Congress of Virology - International Union of Microbiological Societies (IUMS 2014), July 27 - August 1, 2014, Montréal, Québec, Canada, July 27-August 1, 2014, oral presentation, p. 392.
  • Biswas, S., Blissard, G.W., et Theilmann, D.A. (2014). « Investigations into the role of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) AC141 (EXON0) and Trichoplusia ni kinesin-1 in budded virus nucleocapsid egress. », 47th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Johannes Gutenberg University, Mainz, Germany, August 3-7, 2014, p. 44.
  • Erlandson, M.A., Donly, B.C., Theilmann, D.A., Hegedus, D.D., Coutu, C., et Baldwin, D. (2014). « Mamestra configurata nucleopolyhedrovirus-A transcriptome from infected host midgut. », 47th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Johannes Gutenberg University, Mainz, Germany, August 3-7, 2014, oral presentation, p. 80.
  • Erlandson, M.A., Donly, B.C., Theilmann, D.A., Hegedus, D.D., Coutu, C., et Baldwin, D. (2014). « Mamestra configurata nucleopolyhedrovirus-A transcriptome from infected host midgut. », 47th Annual Meeting of the Society for Invertebrate Pathology and International Congress on Invertebrate Pathology and Microbial Control, Mainz, Germany, August 3-7, 2014, Oral Presentation.
  • Erlandson, M.A., Theilmann, D.A., Hegedus, D.L., Donly, T., Gariepy, T.D., et Olfert, O.O. (2014). Bertha armyworm (Mamestra configurata): Genomics, population dynamics and biodiversity of pest and pathogens. Annual Project Report to AAFC-Genomics. (Rapport)
  • Harris, S., Sieminska, E., Theilmann, D.A., Hegedus, D.D., et Erlandson, M.A. (2014). « Interaction between baculovirus infection and Cotesia parasitism in Trichoplusia ni larvae. », 2014 Joint Annual Meeting of Entomological Society of Saskatchewan and Entomological Society of Canada, Saskatoon SK, Canada, September 28-October 1, 2014. (Affiche)

2013

  • Donly, B.C., Theilmann, D.A., Hegedus, D.D., Baldwin, D., et Erlandson, M.A. (2013). « Viral transcription in caterpillar gut infected with the Mamestra configurata nucleopolyhedrosis virus. », Insect Biotech Conference 2013, St. Catharines, Ontario, Canada.

2012

  • Maghodia, A.B., Fang, M.G., Theilmann, D.A., et Erlandson, M.A. (2012). « A group II alphabaculovirus core gene, MacoNPV-A pif-5 (odv-e56), cannot repair the essential per os infectivity function of the AcMNPV-pif5 knockout virus in Trichoplusia ni larvae. », 45th Annual Meeting of the Society for Invertebrate Pathology: 2012 International Congress on Invertebrate Pathology and Microbial Control, Centro de Convenciones UCA, Puerto Madero, Buenos Aires, Argentina, August 5-9, 2012, p. 127.
  • Peng, K., van Lent, J.W.M., Boeren, S., Theilmann, D.A., Erlandson, M.A., Vlak, J.M., et van Oers, M.M. (2012). « Characterization of novel components of the baculovirus per os infectivity factor (PIF) complex. », 45th Annual Meeting of the Society for Invertebrate Pathology: 2012 International Congress on Invertebrate Pathology and Microbial Control, Centro de Convenciones UCA, Puerto Madero, Buenos Aires, Argentina, August 5-9, 2012, p. 127.

2011

  • Erlandson, M.A., Maghodia, A.B., Cossentine, J.E., Lowery, D.T., et Theilmann, D.A. (2011). « Genome structure of a nucleopolyhedrovirus infecting Abagrotis reedi, a cutworm pest of vineyards. », 44th Annual Meeting of the Society for Invertebrate Pathology, Halifax, NS, Canada, August 7-11, 2011. (Affiche)
  • Nie, Y., Fang, M.G., Erlandson, M.A., et Theilmann, D.A. (2011). « Deletion analysis of the AcMNPV gene ac67 (lef-3) encoding the single stranded DNA binding protein and the core gene ac68 shows that LEF-3 is not essential for virus replication. », 30th Annual Meeting of American Society for Virology, University of Minnesota, Minneapolis, MN, USA, July 16-20, 2011.
  • Noakes, A.L., Gillott, C., Hegedus, D.D., Theilmann, D.A., et Erlandson, M.A. (2011). « Mamestra configurata nucleopolyhedrovirus (MacoNPV): potential chitin-binding proteins and their role in oral infectivity. », 44th Annual Meeting of the Society for Invertebrate Pathology, Halifax, NS, Canada, August 7-11, 2011.

2010

  • Erlandson, M.A., Links, M.G., Maghodia, A.B., Donly, B.C., Hegedus, D.D., et Theilmann, D.A. (2010). « Mamestra configurata nucleopolyhedrovirus strain variation at the genome sequence level. », Society for Invertebrate Pathology Conference 2010, Trabzon, Turkey.
  • Toprak, U., Baldwin, D., Hegedus, D.D., Gillott, C., Harris, S., Theilmann, D.A., et Erlandson, M.A. (2010). « Mamestra configurata nucleopolyhedrovirus ENHANCIN substrate specificity and insect intestinal mucin structural types. », Society for Invertebrate Pathology Conference 2010, Trabzon, Turkey.

2009

  • Erlandson, M.A., Links, M.G., Ethier, S., Toprak, U., Hegedus, D.D., et Theilmann, D.A. (2009). « Baculoviruses associated with Mamestra configurata (Bertha Armyworm): Role of viral enhancing factor (VEF) in the infection process. », 8th Workshop on the Molecular Biology and Genetics of the Lepidoptera, Crete, Greece.
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