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Sanfaçon, Hélène, Ph.D.

Chercheuse scientifique

Coordonnées :

4200 Highway 97
C.P. 5000
Summerland, (Colombie-Britannique) V0H 1Z0
Téléphone : 250-494-6393
Télécopieur : 250-494-0755
Courriel : helene.sanfacon@agr.gc.ca

Domaines d'expertise :

  • biologie moléculaire des phytovirus
  • élaboration de méthodes pour la résistance aux phytovirus
  • caractérisation des complexes de réplication des phytovirus
  • caractérisation des facteurs de l'hôte en réplication virale
  • étude des protéases virales et conception d'inhibiteurs
  • caractérisation du virus de la tache annulaire de la tomate
  • développement de qualités de résistance génétique au virus de la sharka
  • caractérisation des virus d'infection des arbres fruitiers et des petits fruits

Projets en cours :

  • Caractérisation des complexes de réplication et de traduction génétique associés aux virus de l'acide ribonucléique des plantes (Sanfacon)
  • Développement de qualités de résistance génétique au virus de la sharka au Canada

Affiliations :

  • Professeure auxiliaire, Département de botanique, Université de la Colombie-Britannique
  • Présidente, Groupe d'étude des Comoviridae, Comité international pour la taxonomie des virus
  • Corédactrice, Journal canadien de botanique

Publications de recherche

2019

  • Siddell, S.G., Walker, P.J., Lefkowitz, E.J., Mushegian, A.R., Adams, M.J., Dutilh, B.E., Gorbalenya, A.E., Harrach, B., Harrison, R.L., Junglen, S., Knowles, N.J., Kropinski, A.M., Krupovic, M., Kuhn, J.H., Nibert, M., Rubino, L., Sabanadzovic, S., Sanfaçon, H., Simmonds, P., Varsani, A., Zerbini, F.M., Davison, A.J. (2019). Additional changes to taxonomy ratified in a special vote by the International Committee on Taxonomy of Viruses (October 2018), 164(3), 943-946. http://dx.doi.org/10.1007/s00705-018-04136-2

2018

  • King, A.M.Q., Lefkowitz, E.J., Mushegian, A.R., Adams, M.J., Dutilh, B.E., Gorbalenya, A.E., Harrach, B., Harrison, R.L., Junglen, S., Knowles, N.J., Kropinski, A.M., Krupovic, M., Kuhn, J.H., Nibert, M.L., Rubino, L., Sabanadzovic, S., Sanfaçon, H., Siddell, S.G., Simmonds, P., Varsani, A., Zerbini, F.M., Davison, A.J. (2018). Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018), 163(9), 2601-2631. http://dx.doi.org/10.1007/s00705-018-3847-1
  • Krupovic M, Blomberg J, Coffin JM, Dasgupta I, Fan H, Geering AD, Gifford R, Harrach B, Hull R, Johnson W, Kreuze JF, Lindemann D, Llorens C, Lockhart B, Mayer J, Muller E, Olszewski NE, Pappu HR, Pooggin MM, Richert-Pöggeler KR, Sabanadzovic S, Sanfaçon H, Schoelz JE, Seal S, Stavolone L, Stoye JP, Teycheney P-Y, Tristem M, Koonin EV, Kuhn JH. 2018. Ortervirales: new virus order unifying five families of reverse-transcribing viruses. J Virol 92:e00515-18. https://doi.org/10.1128/JVI .00515-18.
  • Maes, P., Alkhovsky, S.V., Bào, Y., Beer, M., Birkhead, M., Briese, T., Buchmeier, M.J., Calisher, C.H., Charrel, R.N., Choi, I.R., Clegg, C.S., de la Torre, J.C., Delwart, E., DeRisi, J.L., Di Bello, P.L., Di Serio, F., Digiaro, M., Dolja, V.V., Drosten, C., Druciarek, T.Z., Du, J., Ebihara, H., Elbeaino, T., Gergerich, R.C., Gillis, A.N., Gonzalez, J.P.J., Haenni, A.L., Hepojoki, J., Hetzel, U., Hồ, T., Hóng, N., Jain, R.K., Jansen van Vuren, P., Jin, Q., Jonson, M.G., Junglen, S., Keller, K.E., Kemp, A., Kipar, A., Kondov, N.O., Koonin, E.V., Kormelink, R., Korzyukov, Y., Krupovic, M., Lambert, A.J., Laney, A.G., LeBreton, M., Lukashevich, I.S., Marklewitz, M., Markotter, W., Martelli, G.P., Martin, R.R., Mielke-Ehret, N., Mühlbach, H.P., Navarro, B., Ng, T.F.F., Nunes, M.R.T., Palacios, G., Pawęska, J.T., Peters, C.J., Plyusnin, A., Radoshitzky, S.R., Romanowski, V., Salmenperä, P., Salvato, M.S., Sanfaçon, H., Sasaya, T., Schmaljohn, C., Schneider, B.S., Shirako, Y., Siddell, S., Sironen, T.A., Stenglein, M.D., Storm, N., Sudini, H., Tesh, R.B., Tzanetakis, I.E., Uppala, M., Vapalahti, O., Vasilakis, N., Walker, P.J., Wáng, G., Wáng, L., Wáng, Y., Wèi, T., Wiley, M.R., Wolf, Y.I., Wolfe, N.D., Wú, Z., Xú, W., Yang, L., Yāng, Z., Yeh, S.D., Zhāng, Y.Z., Zhèng, Y., Zhou, X., Zhū, C., Zirkel, F., Kuhn, J.H. (2018). Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018, 163(8), 2295-2310. http://dx.doi.org/10.1007/s00705-018-3843-5
  • Mann, K.S., Chisholm, J., Sanfaçon, H. (2019). Strawberry mottle virus (family Secoviridae, order Picornavirales) encodes a novel glutamic protease to process the RNA2 polyprotein at two cleavage sites, 93(5), http://dx.doi.org/10.1128/JVI.01679-18
  • Paudel, D.B., Ghoshal, B., Jossey, S., Ludman, M., Fatyol, K., Sanfaçon, H. (2018). Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, 524 127-139. http://dx.doi.org/10.1016/j.virol.2018.08.016

2017

  • Adams, M.J., Lefkowitz, E.J., King, A.M.Q., Harrach, B., Harrison, B.L., Knowles, N.J., Kropinski, A.M., Krupovic, M., Kuhn, J.H., Mushegian, A.R., Nibert, M., Sabanadzovic, S., Sanfaçon, H., Siddell, S.G., Simmonds, P., Varsani, A., Zerbini, F.M., Orton, R.J., Smith, D.B., Gorbalenya, A.E. and Davison, A.J. 50 years of the International Committee on Taxonomy of Viruses: progress and prospects. Arch. Virol. 162, 1441-1446
  • Adams, M.J., Lefkowitz, E.J., King, A.M.Q., Harrach, B., Harrison, R.L., Knowles, N.J., Kropinski, A.M., Krupovic, M., Kuhn, J.H., Mushegian, A.R., Nibert, M., Sabanadzovic, S., Sanfaçon, H., Siddell, S.G., Simmonds, P., Varsani, A., Zerbini, F.M., Gorbalenya, A.E., Davison, A.J. (2017). Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017), 162(8), 2505-2538. http://dx.doi.org/10.1007/s00705-017-3358-5
  • Mann, K.S., Walker, M., Sanfaçon, H. (2017). Identification of cleavage sites recognized by the <inf>3</inf>C-like cysteine protease within the two polyproteins of strawberry mottle virus, 8(APR), http://dx.doi.org/10.3389/fmicb.2017.00745
  • Sanfaçon, H. (2017). Grand challenge in plant virology: Understanding the impact of plant viruses in model plants, in agricultural crops, and in complex ecosystems, 8(MAY), http://dx.doi.org/10.3389/fmicb.2017.00860

2016

  • Adams, M.J., Lefkowitz, E.J., King, A.M.Q., Harrach, B., Harrison, R.L., Knowles, N.J., Kropinski, A.M., Krupovic, M., Kuhn, J.H., Mushegian, A.R., Nibert, M., Sabanadzovic, S., Sanfaçon, H., Siddell, S.G., Simmonds, P., Varsani, A., Zerbini, F.M., Gorbalenya, A.E., Davison, A.J. (2016). Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016), 161(10), 2921-2949. http://dx.doi.org/10.1007/s00705-016-2977-6
  • Bhagwat, B., Dickison, V., Ding, X., Walker, M.C., Bernardy, M.G., Bouthillier, M.J., Creelman, A., DeYoung, R.M., Li, Y., Nie, X., Wang, A.M., Xiang, Y., et Sanfaçon, H. (2016). « Genome sequence analysis of five Canadian isolates of Strawberry mottle virus reveals extensive intra-species diversity and a longer RNA2 with increased coding capacity compared to a previously characterized European isolate. », Archives of Virology. doi : 10.1007/s00705-016-2799-6
  • Fuchs, M., Keichinger-Schmitt, C. and Sanfacon, H. (2017) A renaissance in nepovirus research provides new insights into their molecular interface with hosts and vectors. Adv. Virus Res. 97: 61-105
  • Wei, T., Chisholm, J., Sanfaçon, H. (2016). Characterization of a non-canonical signal peptidase cleavage site in a replication protein from tomato ringspot virus, 11(9), http://dx.doi.org/10.1371/journal.pone.0162223

2015

2014

2013

  • Laliberte, J-F., Moffett, P., Sanfaçon, H., Wang, A.M., Nelson, R.S., et Schoelz, J.E. (2013). « e-Book on plant virus infection-a cell biology perspective. », Frontiers in Plant Science, 4(Article 203). doi : 10.3389/fpls.2013.00203
  • Sanfaçon, H. (2013). « Investigating the role of viral integral membrane proteins in promoting the assembly of nepovirus and comovirus replication factories. », Frontiers in Plant Science, 3(Article 313), p. 1-7. doi : 10.3389/fpls.2012.00313
  • Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., et Tian, L.-N. (2013). « Silencing of the Host Factor eIF(iso)4E Gene Confers Plum Pox Virus Resistance in Plum. », PLoS ONE, 8(1, Article No. e50627). doi : 10.1371/journal.pone.0050627
  • Wei, T., Zhang, C., Hou, X., Sanfaçon, H., et Wang, A.M. (2013). « The SNARE protein Syp71 is essential for Turnip mosaic virus infection by mediating fusion of virus-induced vesicles with chloroplasts. », PLoS Pathogens, 9(5), p. e1003378. doi : 10.1371/journal.ppat.1003378
  • Wetzel, T., Chisholm, J., Dupuis-Maguiraga, L., Bassler, A., et Sanfaçon, H. (2013). « In vitro and in vivo evidence for differences in the protease activity of two arabis mosaic nepovirus isolates and their impact on the infectivity of chimeric cDNA clones. », Virology, 446(1-2), p. 102-111. doi : 10.1016/j.virol.2013.07.040

2011

  • Jovel, J., Walker, M.C., et Sanfaçon, H. (2011). « Salicylic acid-dependent restriction of tomato ringspot virus spread in tobacco is accompanied with a hypersensitive response, local RNA silencing and moderate systemic resistance. », Molecular Plant-Microbe Interactions, 24(6), p. 706-718. doi : 10.1094/MPMI-09-10-0224

2010

2009

  • Jafarpour, B. et Sanfaçon, H. (2009). « Insertion of large amino acid repeats and point mutations contribute to a high degree of sequence diversity in the X4 protein of tomato ringspot virus (genus Nepovirus). », Archives of Virology, 154(10), p. 1713-1717. doi : 10.1007/s00705-009-0497-3
  • Sanfaçon, H. (2009). « Secoviridae: the amalgamation of the family Comoviridae and Sequiviridae. », Encyclopedia of Life Sciences, eLS. doi : 10.1002/9780470015902.a0000764.pub2
  • Sanfaçon, H., Wellink, J., Le Gall, O., Karasev, A.V., van der Vlugt, R., et Wetzel, T. (2009). « Secoviridae: a proposed family of plant viruses within the order Picornavirales that combines the families Sequiviridae and Comoviridae, the unassigned genera Cheravirus and Sadwavirus, and the proposed genus Torradovirus. », Archives of Virology, 154(5), p. 899-907. doi : 10.1007/s00705-009-0367-z
  • Wang, A.M., Tian, L.-N., Huang, T.-S., Brown, D.C.W., Svircev, A.M., Stobbs, L.W., Miki, B.L.A., et Sanfaçon, H. (2009). « The development of genetic resistance to plum pox virus in transgenic Nicotiana benthamiana and Prunus domesticus. », Acta Horticulturae (ISHS), 839, p. 665-672.

Autres publications relatives à la science

2015

  • Wei, T., Chisholm, J., et Sanfaçon, H. (2015). « Cleavage of tomato ringspot virus NTP-binding protein by the membrane-associated signal peptidase. », 34th Annual Meeting of American Society for Virology, London, Ontario, Canada, July 11-15, 2015. (Résumé)

2014

  • Ghoshal, B. et Sanfaçon, H. (2014). « Temperature-dependent symptom recovery in Nicotiana benthamiana plants infected with tomato ringspot virus is associated with reduced translation of viral RNA2 and requires ARGONAUTE 1. », International Union of Microbiological Societies Congress (IUMS 2014), Montréal, QC, Canada, July 27-August 1, 2014. (Affiche)
  • Sanfaçon, H. (2014). « Updates to the Plant Virus Taxonomy. », International Union of Microbiological Societies Congresses, Montreal, QC, Canada, July 27-August 1, 2014. (Affiche)
  • Wei, T. et Sanfaçon, H. (2014). « Evidence for in vitro and in vivo cleavage of the C-terminal region of the tomato ringspot virus NTP-binding protein by the membrane-associated signal peptidase. », International Union of Microbiological Societies Congress (IUMS 2014), Montréal, QC, Canada, July 27-August 1, 2014. (Affiche)

2013

  • Ghoshal, B. et Sanfaçon, H. (2013). « Symptom recovery in Nicotiana benthamiana plants infected with tomato ringspot virus is associated with Argonaute 1-dependent translational repression of the viral genome. », Keystone Symposium: RNA Silencing, Whistler Conference Centre, Whistler, BC, Canada, March 19-24, 2013. (Affiche)
  • Karran, R., Walker, M.C., et Sanfaçon, H. (2013). « Tomato ringspot virus coat protein as a potential translational enhancer. », 32nd Annual Meeting of the American Society for Virology, Pennsylvania State University, University Park, Pennsylvania, USA, July 20-24, 2013, (oral presentation).
  • Stobbs, L.W., Hunter, D.M., Samara, R., Lowery, T., Lowery, D.T., et Sanfaçon, H. (2013). « Progress in Epidemiological Research on Plum Pox Virus. », The Tender Fruit Grape Vine (for Commercial Fruit Growers), 17(5), p. 5-6. (Bulletin)
  • Tian, L.-N., Wang, X., Svircev, A.M., Wang, A.M., Sanfaçon, H., Brown, D.C.W., Kohalmi, S.E., et Lu, M. (2013). « Development of Plum pox virus resistance in plum grown in Canada via plant biotechnology. », 2nd International Symposium on Plum Pox Virus, Olomouc, Czech Republic, September 3-6, 2013.
  • Wang, A.M., Elhiti, M., Wang, H., Li, Y., Tian, L.-N., Svircev, A.M., Sanfaçon, H., et Brown, D.C.W. (2013). « Development of genetic resistance to Plum pox virus in Canada. », 2nd International Symposium on Plum Pox Virus, Olomouc, Czech Republic, September 3-6, 2013.
  • Wei, T. et Sanfaçon, H. (2013). « Functional characterization of full-length and truncated forms of the tomato ringspot virus RNA-dependent RNA polymerase. », 32nd Annual Meeting of the American Society for Virology, Pennsylvania State University, University Park, Pennsylvania, USA, July 20-24, 2013. (Affiche)
  • Wetzel, T., Chisholm, J., Dupuis-Maguiraga, L., Bassler, A., et Sanfaçon, H. (2013). « Influence of the protease and polyprotein cleavage efficiency on the infectivity of chimeric Arabis mosaic nepovirus cDNA clones. », Keystone symposium on positive-strand RNA viruses, Boston, Massachussetts, USA, April 28-May 3, 2013. (Affiche)

2012

  • Sanfaçon, H., Walker, M.C., Jovel, J., Karran, R., Ghoshal, B., Chisholm, J., et Wei, T. (2012). « In depth study of the interaction of peach viruses with plant defense responses for improved management of PPV. », Joint Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012. (Présentation)
  • Tian, L.-N., Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., Brown, D.C.W., et Schneider, K.E. (2012). « Control of the expression of the host factor eIF(iso)4E gene for Plum Pox Virus resistance. », Joint Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012. (Présentation)
  • Wei, T., Chisholm, J., et Sanfaçon, H. (2012). « Stability of the tomato ringspot virus RNA-dependent RNA polymerase in plants: exploring possible interactions with components of the proteaseome and with caspase-like proteases. », XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Résumé)

2011

  • Ghoshal, B. et Sanfaçon, H. (2011). « Accumulation of viral products during the symptomatic and recovery phase in Nicotiana benthamiana plants infected with tomato ringspot virus isolates differing in their virulence. », XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Présentation)
  • Sanfaçon, H. et Fuchs, M. (2011). « Tomato ringspot virus. », dans Hadidi, A., Barba, M., Candresse, T., and Jelkmann, W. (dir.) - Virus and Virus-Like Diseases of Pome and Stone Fruits, American Phytopathological Society (APS), Chapitre 9, Part II. Pome Fruit Viruses and Related Diseases.
  • Sanfaçon, H., Gorbalenya, A.E., Knowles, N.J., et Chen, Y. (2011). « Order Picornavirales. », dans King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. (dir.) - Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Elsevier, p. 835-839.
  • Sanfaçon, H., Iwanami, T., Karasev, A.V., van der Vlugt, R., Wellink, J., Wetzel, T., et Yoshikawa, N. (2011). « Family Secoviridae. », dans King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. (dir.) - Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Elsevier, p. 881-899.
  • Wei, T., Chisholm, J., et Sanfaçon, H. (2011). « Sequence analysis of RNA1-encoded replication proteins of tomato ringspot nepovirus isolates. », XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Affiche)

2010

  • Brown, D.C.W., Wang, A.M., Tian, L.-N., Svircev, A.M., Sanfaçon, H., et Miki, B.L.A. (2010 Internal). Developmnt of genetic resistance to PPV in Prunus Sp. Research Report to the Plum Pox Virus Working Group, St. Catherines, Ontario, January 26-28, 2010. (Rapport)
  • Sanfaçon, H. (2010). « Emerging technologies for the control of plant virus diseases. », dans Wang, A. (dir.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India, Chapitre 17, p. 295-310.
  • Tian, L.-N., Svircev, A.M., Sanfaçon, H., et Brown, D.C.W. (2010). « Plum pox virus resistance stability and expression of specific siRNAs in plum. », US/Canada Plum Pox Virus Update and International Research Symposium, Kearneysville, WV, USA, January 4-6, 2010.

2009

  • Brown, D.C.W., Wang, A.M., Tian, L.-N., Svircev, A.M., Sanfaçon, H., et Miki, B.L.A. (2009 Internal). Developing genetic resistance to Plum Pox Virus. Research Report to the Plum Pox Virus Working Group, St Catherines, Ontario, January 27, 2009. (Rapport)
  • Le Gall, O., Sanfaçon, H., Ikegami, M., Iwanami, T., Jones, T., Karasev, A.V., Lehto, K., Wellink, J., Wetzel, T., et Yoshikawa, N. (2009). « Cheravirus and Sadwavirus: Two unassigned genera of plant positive-sense single-stranded RNA viruses formerly considered atypical members of the genus Nepovirus (family Comoviridae) [Archives of Virology 152(9), pp.1767-1774] (Erratum). », Archives of Virology, 154(6), p. 1019.
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