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Gouvernement du Canada / Government of Canada

Recherche

Alexander, Trevor, Ph.D.

Chercheur scientifique

Coordonnées :

5403 1ère Avenue Sud
Lethbridge, Alberta T1J 4B1
Téléphone : 403-317-2158
Télécopieur : 403-382-3156
Courriel : trevor.alexander@agr.gc.ca

Domaines d'expertise :

  • Physiologie du boeuf
  • Santé des ruminants
  • Maladie respiratoire bovine
  • Transmission des pathogèns et stratégies de contrôles
  • Microbiologie environementale
  • Microbiologie du rumen
  • Résistance aux antibiotiques

Projets en cours :

  • Élucidation des facteurs impliqués dans l’apparition et le résultat de la maladie respiratoire bovine, incluant l’immunité innée, la nutrition, la virulence du pathogène, et les bactéries de l’hôte
  • Application de la vaccinologie inverse pour identifier des nouveaux antigènes pour le développement de vaccins contre Mannheimia haemolytica
  • Épidémiologie et charactérisation des pathogènes du bovin et de la résistance aux antibiotiques

Publications de recherche

2020

  • Zhang, Y., Gao, X., Hao, X., Alexander, T.W., Shi, X., Jin, L., Thomas, B.W. (2020). Heavy grazing over 64 years reduced soil bacterial diversity in the foothills of the Rocky Mountains, Canada, 147 http://dx.doi.org/10.1016/j.apsoil.2019.09.011

2019

  • Holman, D.B., Yang, W., Alexander, T.W. (2019). Antibiotic treatment in feedlot cattle: A longitudinal study of the effect of oxytetracycline and tulathromycin on the fecal and nasopharyngeal microbiota, 7(1), http://dx.doi.org/10.1186/s40168-019-0696-4
  • Klima, C.L., Holman, D.B., Ralston, B.J., Stanford, K., Zaheer, R., Alexander, T.W., McAllister, T.A. (2019). Lower Respiratory Tract Microbiome and Resistome of Bovine Respiratory Disease Mortalities, 78(2), 446-456. http://dx.doi.org/10.1007/s00248-019-01361-3

2018

  • Zhang, Y., Hao, X., Alexander, T.W., Thomas, B.W., Shi, X., Lupwayi, N.Z. (2018). Long-term and legacy effects of manure application on soil microbial community composition, 54(2), 269-283. http://dx.doi.org/10.1007/s00374-017-1257-2

2016

  • Holman, D.B., Hao, X., Topp, E., Yang, H.E., Alexander, T.W. (2016). Effect of co-composting cattle manure with construction and demolition waste on the archaeal, bacterial, and fungal microbiota, and on antimicrobial resistance determinants, 11(6), 1-21. http://dx.doi.org/10.1371/journal.pone.0157539
  • Timsit, E., Workentine, M., Schryvers, A.B., Holman, D.B., Van Der Meer, F., et Alexander, T.W. (2016). « Evolution of the nasopharyngeal microbiota of beef cattle from weaning to 40 days after arrival at a feedlot. », Veterinary Microbiology, 187, p. 75-81. doi : 10.1016/j.vetmic.2016.03.020

2015

2014

2013

  • Alexander, T.W., Cook, S.R., Klima, C.L., Topp, E., et McAllister, T.A. (2013). « Susceptibility to tulathromycin in Mannheimia haemolytica isolated from feedlot cattle over a three-year period. », Frontiers in Microbiology, 4(297). doi : 10.3389/fmicb.2013.00297
  • Alexander, T.W., Jin, X., Li, Q., Cook, S.R., et McAllister, T.A. (2013). « Characterization of tetracycline resistance genes in Escherichia coli isolated from feedlot cattle administered therapeutic or subtherapeutic levels of tetracycline. », Canadian Journal of Microbiology, 59(4), p. 287-290. doi : 10.1139/cjm-2012-0660
  • Hsu, Y.-H., Cook, S.R., Alexander, T.W., Klima, C.L., Niu, Y.D., Selinger, L.B., et McAllister, T.A. (2013). « Investigation of Mannheimia haemolytica bacteriophages relative to host diversity. », Journal of Applied Microbiology, 114(6), p. 1592-1603. doi : 10.1111/jam.12185
  • Klima, C.L., Alexander, T.W., Hendrick, S., et McAllister, T.A. (2013). « Characterization of Mannheimia haemolytica isolates collected from the nasopharynx of morbid and healthy feedlot cattle in western Canada. », Canadian Journal of Veterinary Research, 78(1), p. 38-45.
  • Klima, C.L., Cook, S.R., Hahn, K.R., Amoako, K.K., Alexander, T.W., Hendrick, S., et McAllister, T.A. (2013). « Draft genome sequence of a Mannheimia haemolytica serotype 6 isolate collected from the nasopharynx of a beef calf with bovine respiratory disease. », Genome Announcements, 1(2: e0005113). doi : 10.1128/genomeA.00051-13
  • Narvaez, N., Wang, Y., Xu, Z.J., Alexander, T.W., Garden, S., et McAllister, T.A. (2013). « Effects of hop varieties on ruminal fermentation and bacterial community in an artificial rumen (rusitec). », Journal of the Science of Food and Agriculture, 93(1), p. 45-52. doi : 10.1002/jsfa.5725
  • Zaheer, R., Cook, S.R., Klima, C.L., Stanford, K.I.M., Topp, E., Read, R.R., et McAllister, T.A. (2013). « Effects of subtherapeutic vs therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and Enterococci isolated from beef cattle. », BMC Biochemistry, 4(article 133). doi : 10.3389/fmicb.2013.00133

2012

2011

  • Alexander, T.W., Yanke, L.J., Reuter, T.R., Topp, E., Read, R.R., Selinger, L.B., et McAllister, T.A. (2011). « Longitudinal characterization of antimicrobial resistance genes in feces shed from cattle fed different subtherapeutic antibiotics. », BMC Microbiology, 11:19. doi : 10.1186/1471-2180-11-19
  • Klima, C.L., Alexander, T.W., Read, R.R., Gow, S.P., Booker, C.W., Hannon, S., Sheedy, C., McAllister, T.A., et Selinger, L.B. (2011). « Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. », Veterinary Microbiology, 149(3-4), p. 390-398. doi : 10.1016/j.vetmic.2010.11.018
  • Reuter, T.R., Alexander, T.W., et McAllister, T.A. (2011). « Viability of Bacillus licheniformis and Bacillus thuringiensis spores as a model for predicting the fate of Bacillus anthracis spores during composting of livestock mortalities. », Applied and Environmental Microbiology, 77(5), p. 1588-1592. doi : 10.1128/AEM.01889-10
  • Wu, R.-B., Alexander, T.W., Li, J.-Q., Munns, K., Sharma, R., et McAllister, T.A. (2011). « Prevalence and diversity of class 1 integrons and resistance genes in antimicrobial-resistant Escherichia coli originating from beef cattle administered subtherapeutic antimicrobials. », Journal of Applied Microbiology, 111(2), p. 511-523. doi : 10.1111/j.1365-2672.2011.05066.x

2010

  • Alexander, T.W., Inglis, G.D., Yanke, L.J., Topp, E., Read, R.R., Reuter, T.R., et McAllister, T.A. (2010). « Farm-to-fork characterization of Escherichia coli associated with feedlot cattle with a known history of antimicrobial use. », International Journal of Food Microbiology, 137(1), p. 40-48. doi : 10.1016/j.ijfoodmicro.2009.11.008
  • Klima, C.L., Alexander, T.W., Selinger, L.B., Read, R.R., Shewan, P.E., Gow, S.P., Booker, C.W., et McAllister, T.A. (2010). « Comparison of repetitive PCR and pulsed-field gel electrophoresis for the genotyping of Mannheimia haemolytica. », Journal of Microbiological Methods, 81(1), p. 39-47. doi : 10.1016/j.mimet.2010.01.020
  • Reuter, T.R., Alexander, T.W., Xu, W., Stanford, K.I.M., et McAllister, T.A. (2010). « Biodegradation of genetically modified seeds and plant tissues during composting. », Journal of the Science of Food and Agriculture, 90(4), p. 650-657. doi : 10.1002/jsfa.3863
  • Reuter, T.R., Xu, W., Alexander, T.W., Gilroyed, B.H., Inglis, G.D., Larney, F.J., Stanford, K.I.M., et McAllister, T.A. (2010). « Biocontained carcass composting for control of infectious disease outbreak in livestock. », Journal of Visualized Experiments (JoVE), 39(Article No. e1946). doi : 10.3791/1946
  • Yang, H.E., Yang, W.-Z., McKinnon, J.J., Alexander, T.W., et McAllister, T.A. (2010). « Survival of Escherichia coli O157:H7 in ruminal or fecal contents incubated with corn or wheat dried distillers' grains with solubles. », Canadian Journal of Microbiology, 56(11), p. 890-895. doi : 10.1139/W10-077

2009

Autres publications relatives à la science

2015

  • Hao, X., Larney, F.J., Ellert, B.H., Alexander, T.W., et McAllister, T.A. (2015). « Co-composting cattle feedlot manure with construction and demolition waste. », International Compost Conference, Beijing, China, November 22-25, 2015. (Résumé)
  • McAllister, T.A., Aslam, M., Bach, S.J., Alexander, T.W., Stanich, K., et McGinn, S.M. (2015). Defining the contribution of super-shedders to high event days in commercial abattoirs and contamination of the environment with Escherichia coli O157:H7. Research Project Annual Report. AAFC Project ID J-000119. (Rapport)
  • Reich, J., Chatterton, S., et Alexander, T.W. (2015). « Development of a multiplex qPCR TaqMan assay for the quantification of airborne spores of Botrytis cinerea and Sclerotinia sclerotiorum. », Botany 2015, Shaw Convention Center, Edmonton, Alberta, Canada, July 25-29, 2015. (Résumé)

2014

  • Alexander, T.W., McAllister, T.A., Stanford, K.I.M., Reuter, T.R., et Topp, E. (2014). « Characterization of Shiga toxin-producing Escherichia coli isolated from feces of cattle in commercial feedlots. », ADSA-ASAS 2014 Joint Annual Meeting, Kansas City, MO, USA, July 20-24, 2014.
  • Hao, X., Hill, B.D., Caffyn, P.R., Travis, G.R., Olsen, P.A., Larney, F.J., McAllister, T.A., et Alexander, T.W. (2014). « Co-composting of beef cattle feedlot manure with construction and demolition waste. », 51st Annual Alberta Soil Science Workshop, Calgary, AB, Canada, February 12-14, 2014. (Résumé)
  • Hao, X., Hill, B.D., Caffyn, P.R., Travis, G.R., Olson, A.F., Larney, F.J., McAllister, T.A., et Alexander, T.W. (2014). « Co-composting of beef cattle feedlot manure with housing construction waste for value-added organic fertilizer. », 51st Annual Alberta Soil Science Workshop, Calgary, AB, Canada, February 12-14, 2014, p. 30. (Résumé)
  • Hao, X., Larney, F.J., Alexander, T.W., et McAllister, T.A. (2014). « Co-composting beef cattle feedlot manure with construction & demolition (C&D) waste. », ASA, CSSA and SSSA International Annual Meeting 2014, Long Beach, CA, USA, November 2-5, 2014, Oral presentation. (Résumé)
  • Jin, L., Li, C., He, M.L., Wang, Y., Alexander, T.W., et McAllister, T.A. (2014). « Effects of echium and flaxseed oil on ruminal fatty acid metabolism in vitro. », ADSA-ASAS 2014 Joint Annual Meeting, Kansas City, MO, USA, July 20-24, 2014.
  • McAllister, T.A., Aslam, M., Bach, S.J., Alexander, T.W., Stanich, K., et McGinn, S.M. (2014). Defining the contribution of super-shedders to high event days in commercial abattoirs and contamination of the environment with Escherichia coli O157:H7. Research Project Annual Report. AAFC Project ID J-000119. (Rapport)

2013

  • Alexander, T.W. (2013). « Antimicrobial use and livestock production. », Pacific NorthWest Economic Region annual summit, Anchorage, Alaska, USA, July 14-18, 2013. (Présentation)
  • Alexander, T.W. (2013). « DNA extraction and PCR methods. », CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013.
  • Jin, L., He, M.L., Wang, Y., Alexander, T.W., Kraft, J., Li, C., Zhang, Y.G., et McAllister, T.A. (2013). « In vitro effects of echium oil and flaxseed oil on major rumen bacterial populations. », CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013, P48, p. 45. (Affiche)
  • Klima, C.L., Zaheer, R., Hendrick, S., Alexander, T.W., et McAllister, T.A. (2013). « Agents of Bovine Respiratory Disease in North American Feedlots. », CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013, O13-GS, p. 8.
  • Subramanian, S., McAllister, T.A., Baah, J., et Alexander, T.W. (2013). « Analysis of probiotic bacteria to inhibit the respiratory pathogen Mannheimia haemolytica and adhere to bovine bronchial epithelial cells in vitro. », CSAS-CMSA Joint Annual Meeting, Banff Park Lodge Resort Hotel and Conference Centre, Banff, AB, Canada, June 18-20, 2013, P57, p. 49. (Affiche)

2012

  • Alexander, T.W. et McAllister, T.A. (2012). « Manipulating the ruminant microbiota to improve production. », 48th Annual Eastern Nutrition Conference of the Animal Nutrition Association of Canada (ANAC), Kitchener, ON, Canada, May 9-10, 2012.
  • Alexander, T.W. et McAllister, T.A. (2012). « Manipulating the ruminant microbiota to improve production. », DSM Pharmaceuticals Confernence: Probiotics, Rheinfelden, Switzerland, 1-2 February, 2012. (Présentation)
  • Alexander, T.W., Wright, A.-D.G., et McAllister, T.A. (2012). « Comparison of the Bacterial Microbiota in Nasopharyngeal Samples from Cattle Treated for Bovine Respiratory Disease and Cattle with no History of Disease. », 112th General Meeting of American Society for Microbiology, San Francisco, CA, USA, June 15-19, 2012.

2011

  • Klima, C.L., McAllister, T.A., Hendrick, S., et Alexander, T.W. (2011). « Antimicrobial susceptibility and genetic characterization of Mannheimia haemolytica isolates from the nasopharynx of feedlot cattle in western Canada. », Antimicrobial stewardship in Canadian agriculture and veterinary medicine conference: How is Canada doing and what still needs to be done?, Toronto Airport, Toronto, ON, Canada, October 30-November 2, 2011.
  • McAllister, T.A., Alexander, T.W., Cook, S.R., Yanke, L.J., et Zaheer, R. (2011). « Molecular Ecology of Antimicrobial Resistance in the Feedlot. », Antimicrobial Stewardship in Canadian Agriculture and Veterinary Medicine: How is Canada doing and what still needs to be done?, Toronto Airport, Toronto, ON, Canada, October 30- November 2, 2011.
  • Reuter, T.R., Alexander, T.W., et McAllister, T.A. (2011). « Detection of genetically modified feed and food. », dans Fink-Gremmels, J. (dir.) - Animal Feed Contamination: Effects on Livestock and Food Safety, Woodhead Publishing, Cambridge, UK.
  • Wu, R.-B., Alexander, T.W., Li, J.-Q., Munns, K., Sharma, R., et McAllister, T.A. (2011). « Characterization of class 1 integrons and resistance genes in antimicrobial-resistant Escherichia coli in beef cattle. », Antimicrobial stewardship in Canadian agriculture and veterinary medicine conference: How is Canada doing and what still needs to be done?, Toronto Airport, Toronto, ON, Canada, October 30-November 2, 2011.
  • Zaheer, R., Cook, S.R., Klima, C.L., Read, R.R., Alexander, T.W., et McAllister, T.A. (2011). « Characterization of Mannheimia haemolytica and other erythromycin resistant nasopharyngeal microbes from macrolide-treated feedlot cattle. », Antimicrobial stewardship in Canadian agriculture and veterinary medicine conference: How is Canada doing and what still needs to be done?, Toronto Airport, Toronto, ON, Canada, October 30-November 2, 2011.

2010

  • Alexander, T.W., Stanford, K.I.M., et McAllister, T.A. (2010). « On-farm mitigation of enteric pathogens to prevent human disease. », dans Krause, D. and Hendrick, S. (dir.) - Zoonotic Pathogens in the Food Chain, CABI Publishing, Chapitre 7, p. 140-166.

2009

  • Alexander, T.W., Inglis, G.D., Yanke, L.J., Topp, E., et McAllister, T.A. (2009). « Characterization of antimicrobial-resistant Escherichia coli from samples collected throughout processing of feedlot cattle at a commercial abattoir. », ADSA-CSAS-ASAS 2009 Joint Annual Meeting, Montréal Convention Center, Montréal, QC, Canada, July 12-16, 2009. (Affiche)
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