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Cryopreservation of Mammalian Oocytes

Anzar M. (2017) "Cryopreservation of Mammalian Oocytes" in “Animal Model and Human Reproduction” by John Wiley & Sons (2017). Eds: Heide Schatten and George Constantinescu

Abstract

Oocyte cryopreservation is useful for fertility preservation in human, and conservation and exploitation of female genetics in livestock species. It is more challenging in farm animals than human. For successful oocyte cryopreservation using slow freezing, the main approach should be to minimize the lethal intracellular ice formation during cooling and warming, the solution effect due to cell dehydration as well as the toxicity of permeating cryoprotectants. An ideal vitrification procedure should minimize the osmotic shock, cytotoxicity of permeating cryoprotectants and intracellular ice formation. Unlike embryos, the mammalian oocytes do not undergo true vitrification. There is a dire need of oocyte-specific cryopreservation protocol for successful fertility preservation and genetic conservation programs.

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