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A DNA element that remembers winter.

Li C, Cui Y. (2016) A DNA element that remembers winter. Nature Genetics 48(12):1451-1452. doi: 10.1038/ng.3727.  Access to full text


Polycomb-mediated silencing of the floral repressor gene FLC in response to long-term cold is a central event during vernalization in Arabidopsis thaliana, but how it is initiated is unclear. Two new studies identify a DNA element that mediates FLC silencing by attracting a pair of transcriptional repressors, VAL1 and VAL2, which in turn trigger epigenetic silencing by the Polycomb complex PHD-PRC2.

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