NMR structural studies of Fusarium secondary metabolites.
Blackwell, B., Bahadoor, A., Bosnich, W., Schneiderman, D., Aubin, Y., Harris, L.J. NMR structural studies of Fusarium secondary metabolites. 29th Annual MOOT NMR Conference, Charlottetown, PEI, Sept 30 – Oct 2, 2016. Poster presentation.
The genome of Fusarium graminearum contains a significant number of both clustered and singular genes involved in secondary metabolism, many of which are expressed during plant infection and may play a role in pathogenicity. With the exception of the trichothecene gene cluster which is well characterized, many of the products of these genes remain undetermined. At ORDC, there is the capability of producing a variety of selective gene disruptants of Fusarium which permits the characterization of novel secondary metabolites associated with the target gene when cultured in liquid media. NMR is extensively used in the structural determination of these gene products, the elucidation of biosynthetic pathways and the characterization of metabolite profiles. This is illustrated by three examples of recent projects.
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