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New azaphilones from Chaetomium globosum isolated from the built environment

McMullin, D.R., Sumarah, M.W., Blackwell, B.A., Miller, J.D. (2013). New azaphilones from Chaetomium globosum isolated from the built environment, 54(6), 568-572. http://dx.doi.org/10.1016/j.tetlet.2012.11.084

Abstract

A strain of Chaetomium globosum (DAOM 240359) was isolated from an indoor air sample in Ottawa, Ontario, Canada. When fermented in liquid culture, this strain produced a number of known metabolites including chaetoglobosins A (6), C, and F (7), chaetomugilin D (5), chaetoviridin A (4), and three new nitrogenous azaphilones; 4′-epi-N-2-hydroxyethyl-azachaetoviridin A (1), N-2-butyric-azochaetoviridin E (2), and isochromophilone XIII (3). The structures were elucidated by spectroscopic analysis including; HRMS, 1D and 2D NMR, UV, and ORD. Compounds 2-7 were antimicrobial when tested using quantitative growth inhibition assays. © 2012 Published by Elsevier Ltd.

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