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Antioxidant and anti-Inflammatory activities of bean (Phaseolus vulgaris L.) Hulls

Oomah, B.D., Corbé, A., Balasubramanian, P. (2010). Antioxidant and anti-Inflammatory activities of bean (Phaseolus vulgaris L.) Hulls, 58(14), 8225-8230. http://dx.doi.org/10.1021/jf1011193

Abstract

Hulls obtained by mechanical abrasive dehulling from four bean cultivars were extracted with two solvents, aqueous (70%) acetone and water, and the extracts evaluated for antioxidant and anti-inflammatory activities in relation to their phenolic contents. Total phenolic content and antioxidant activity of bean hulls, measured using oxygen radical absorbance capacity (ORAC) values, were 6-8-fold those of corresponding whole beans. Aqueous acetone (70%) extracted over twice the amount of total phenolics from hulls that exhibited significantly higher antioxidant and stronger inhibitory effect on both cyclooxygenases, COX-1 and COX-2, than water. Acetone extract of black bean hull exhibited strong COX-1 (IC50 = 1.2 μg/mL) and COX-2 (IC 50 = 38 μg/mL) inhibitory effects, even outperforming aspirin. Bean hull water extracts were stronger inhibitors of lipoxygenase, 15-LOX, than corresponding acetone extracts. Anti-inflammatory activity of bean hulls was dependent on their phenolic content and antioxidant activity that were significantly affected by cultivar and extracting solvent. © Published 2010 by the American Chemical Society.

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