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Dietary purified oat β-glucan reduces peak glucose absorption and portal insulin release in portal-vein catheterized grower pigs

Hooda, S., Matte, J.J., Vasanthan, T., Zijlstra, R.T. (2010). Dietary purified oat β-glucan reduces peak glucose absorption and portal insulin release in portal-vein catheterized grower pigs, 134(1-3), 15-17. http://dx.doi.org/10.1016/j.livsci.2010.06.083

Abstract

Kinetics of glucose absorption may affect insulin secretion into the portal vein. The role of wet-fractionated oat β-glucan on these variables is unknown; thus, three 35-kg pigs were fitted with catheters in the portal vein and carotid artery and a portal vein flow probe. Pigs were fed 3 diets containing 0, 3, or 6% purified β-glucan for 7-d in a repeated 3 × 3 Latin square. On d 7, blood was sampled for 12. h postprandially. Net glucose absorption rate was calculated from plasma portal-arterial differences × flow. Blood flow increased (P<0.001) after feeding, without a diet effect. Postprandially, β-glucan reduced (P<0.05) net glucose absorption during the first h by 22 to 51%. At 30 and 90. min postprandially, β-glucan decreased (P<0.05) portal release of C-peptide but did not affect portal insulin at 30. min, indicating that β-glucan reduces peak insulin release while maintaining prehepatic insulin homeostasis. In conclusion, oat β-glucan as a soluble, viscous fibre decreases rate of glucose absorption and peak insulin release in portal vein. © 2010 Elsevier B.V.

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