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Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice

Li, C., Nie, S.P., Zhu, K.X., Xiong, T., Li, C., Gong, J., Xie, M.Y. (2015). Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice, 66(5), 533-538. http://dx.doi.org/10.3109/09637486.2015.1024204

Abstract

© 2015 Informa UK Ltd. All rights reserved. Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5mg kg<sup>-1</sup>) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10<sup>7</sup> CFU/mL; NCU116-M, 10<sup>8</sup> CFU/mL; NCU116-H, 10<sup>9</sup> CFU/mL; respectively). Mice were treated with the probiotic for 15d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation.

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