Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα, FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers.

Han, C., Vinsky, M.D., Aldai, N., Dugan, M.E.R, McAllister, T.A., and Li, C. (2013). "Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα, FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers.", Meat Science, 93(3), pp. 429-436. doi : 10.1016/j.meatsci.2012.10.006  Access to full text

Abstract

Two previously reported DNA polymorphisms of sterol regulatory element binding transcription factor 1 (SREBP1) and liver X receptor alpha (LXRα) and two DNA polymorphisms of fatty acid desaturase 1 (FADS1) were evaluated for associations with fatty acids in brisket adipose tissue of Canadian cross-bred beef steers. The polymorphism of 84 bp insert/deletion in intron 5 of SREBP1 was significantly associated with the concentration of 9c C17:1 (P = 0.013). The G > A single nucleotide polymorphism (SNP) in the exon 4 of LXRα gene was associated with the concentration of 9c, 11 t C18:2 (P = 0.04), sum of conjugated linoleic acids (CLA) (P = 0.025) and 11c C20:1(P = 0.042). Two DNA polymorphisms in the promoter region of FADS1, deletion/insertion of - > GTG in rs133053720 and SNP A > G in rs42187276, were significantly associated with concentrations of C17:0 iso, C17:0 ai, total branched chain fatty acids (BFA), 12 t C18:1, 13 t/14 t C18:1, 15 t C18:1, and 13c C18:1 (P < 0.05). Further studies are needed to validate the associations and to delineate the roles of the gene polymorphisms in determining the fatty acid composition in beef tissues.

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