Immunomodulatory properties of fermented soy and dairy milks prepared with lactic acid bacteria.

Wagar, L.E., Champagne, C.P., Buckley, N.D., Raymond, Y., and Green-Johnson, J.M. (2009). "Immunomodulatory properties of fermented soy and dairy milks prepared with lactic acid bacteria.", Journal of Food Science, 74(8), pp. M423-M430(1). doi : 10.1111/j.1750-3841.2009.01308.x  Access to full text


Fermented soy and dairy milk preparations provide a means for delivering lactic acid bacteria and their fermentation products into the diet. Our aims were to test immunomodulatory bioactivity of fermented soy beverage (SB) and dairy milk blend (MB) preparations on human intestinal epithelial cells (IEC) and to determine the impact of freezing medium on culture survival prior to bioactivity analyses. Fermented SB and MB were prepared using pure or mixed cultures  ofStreptococcus thermophilus ST5, Bifidobacterium longumR0175,   andLactobacillus helveticusR0052. Immunomodulatory bioactivity was  assessed by testing selected SB and MB ferments on tumor necrosis factor α (TNFα)-treated IEC and measuring effects on Interleukin-8 (IL-8) production. Impact of timing of ferment administration relative to this pro-inflammatory challenge was investigated. The most pronounced reductions in IEC IL-8 production were observed when IEC were treated with either SB or MB ferment preparations prior to TNFα challenge. These results indicate that freezing-stable MB and SB ferments prepared with selected strains can modulate  IEC IL-8 productionin vitro, and suggest that yogurt-like fermented soy formulations could provide a functional food alternative to milk-based fermented products.

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